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| Titre : | Prevalence, risk factors and clinical signs predictive for equine pituitary pars intermedia dysfunction in aged horses (2013) |
| Auteurs : | T. MCGOWAN W. ; C.M. Mcgowan ; G. PINCHBECK P. |
| Type de document : | Article : texte imprimé |
| Dans : | EQUINE VETERINARY JOURNAL (vol.45, n1, 2013-01-01) |
| Article en page(s) : | p 74-79 |
| Langues: | Anglais |
| Mots-clés : |
Equivoc Cheval Âgé ; Épidémiologie ; Syndrome De Cushing ; Système Endocrinien |
| Résumé : | Reasons for performing study: Equine pituitary pars intermedia dysfunction (PPID) is an ageing-related neurodegenerative disorder. The prevalence and risk factors for PPID using seasonally adjusted basal adrenocorticotropic hormone (ACTH) concentrations in aged horses have not been previously reported. Objectives: To determine the prevalence, risk factors and clinical signs predictive for PPID in a population of horses aged ?15 years in Queensland, Australia. Methods: Owner-reported data was obtained using a postal questionnaire distributed to an equestrian group. A subgroup of surveyed owners were visited and a veterinary physical examination performed on all horses aged ?15 years. Blood samples were analysed for basal plasma alpha melanocyte-stimulating hormone (?-MSH) and ACTH concentrations, routine haematology and selected biochemistry. Aged horses with elevations above seasonally adjusted cut-off values for basal plasma ACTH were considered positive for PPID. Positive horses were compared with their aged counterparts to determine risk factors and clinical signs associated with PPID. Results: Pituitary pars intermedia dysfunction was prevalent in aged horses (21.2%) despite owners infrequently reporting it as a known or diagnosed disease or disorder. Numerous clinical or historical signs were associated with an increased risk of PPID in the univariable model, but only age (odds ratio (OR) 1.18; 95% confidence interval (CI) 1.11\2261.25, P<0.001) and owner-reported history of hirsutism (OR 7.80; 95% CI 3.67\22616.57, P<0.001) remained in the final multivariable model. There were no routine haematological or biochemical variables supportive of a diagnosis of PPID. Conclusions and potential relevance: Pituitary pars intermedia dysfunction occurs commonly in aged horses despite under-recognition by owners. The increased risk of PPID with age supports that this is an ageing associated condition. Aged horses with clinical or historical signs consistent with PPID, especially owner-reported hirsutism (delayed shedding and/or long hair coat), should be tested and appropriate treatment instituted. |
| Cote du document numérique : | 15815 |
| Classement cheval : | F18 |
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| Code-barres | Cote | Support | Localisation | Section | Disponibilité |
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| 106273 | EVJ | Revue | Haras national du Pin | Indéterminé | Exclu du prêt |