My documentary account
| Title: | Recovery of insulin sensitivity in mature horses after a 3 week course of dexamethasone therapy (2014) |
| Authors: | K.M. Brennan ; K.L. Urschel |
| Material Type: | Article : printed text |
| In : | EQUINE VETERINARY JOURNAL (vol.46 (6)) |
| Article on page: | p.718-721 |
| Languages: | English |
| Descriptors: |
Mots-clés cheval GLYCEMIEEquivoc Anti Inflammatoire ; Glucose ; Insuline ; Pharmacologie |
| Abstract: | Reasons for performing the study: Dexamethasone is an anti-inflammatory drug commonly used in equine medicine. Insulin sensitivity decreases with prolonged dexamethasone administration, but little information is available about the duration of this side effect after long-term treatment ends. Objectives: To determine how long it takes for blood glucose, insulin and markers of insulin sensitivity to return to normal ranges after extended dexamethasone treatment has ceased. Study design: Experimental study. Methods: Eight healthy, mature, mixed-breed horses received 0.04 mg/kg bwt/day oral dexamethasone for 21 days. Blood samples were taken weekly during dexamethasone treatment (Days -21, -14 and -7). Following the final dose of dexamethasone on Day 0, blood samples were taken on Days 1\2266, 8, 10, 12, 15 and 22. Day -21 represents baseline or normal blood predexamethasone. Results: On Day 1, plasma glucose and insulin concentrations and the modified insulin-to-glucose ratio (a proxy for pancreatic ? cell responsiveness) were higher and the reciprocal of the square root of insulin (a proxy for the estimate of insulin sensitivity) was lower, in comparison with Day -21 values. Blood glucose concentrations dropped and returned to Day -21 values by Day 2. Insulin concentrations remained elevated until Day 3. Values for the modified insulin-to-glucose ratio decreased and returned to Day -21 concentrations by Day 4. Values for the reciprocal of the square root of insulin did not return to Day -21 values until Day 15. Conclusions: These results indicate that, in contrast to blood glucose concentrations, which return to normal quickly (within 2 days after treatment ends), the pancreatic insulin-secreting response has a delayed recovery. |
| Cote du document numérique : | 16733 |
| Classement cheval : | F11 |
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| Barcode | Call number | Media type | Location | Section | Status |
|---|---|---|---|---|---|
| 106121 | EVJ | Revue | Haras national du Pin | Indéterminé | Not for loan |