Titre : | 17 béta-estradiol regulates cyclin A1 and cyclin B1 gene expression in adult rat seminiferous tubules (2012) |
Auteurs : | C. Bois ; C. Delalande ; H. Bouraïma-Lelong ; Philippe Durand ; S. Carreau |
Type de document : | Article : texte imprimé |
Dans : | JOURNAL OF MOLECULAR ENDOCRINOLOGY (48, 2012-01-01) |
Article en page(s) : | p.89-97 |
Langues: | Anglais |
Mots-clés : |
Mots-clés cheval ESTRADIOL ; OESTROGENEEquivoc Gène ; Hormone De Reproduction ; Pharmacologie ; Spermatogenèse |
Résumé : | Spermatogenesis, which is the fundamental mechanism allowing male gamete production, is controlled by several factors, and among them, estrogens are likely concerned. In order to enlighten the potential role of estrogen in rat spermatogenesis, seminiferous tubules (ST) from two groups of seminiferous epithelium stages (II\226VIII and IX\226I) were treated with either 17b-estradiol (E2) agonists or antagonists for estrogen receptors (ESRs). In this study, we show that cyclin A1 and cyclin B1 gene expression is controlled by E2 at a concentration of 10K9 M only in stages IX\226I. This effect is mimicked by a treatment with the G-protein coupled estrogen receptor (GPER) agonist G1 and is abolished by treatment with the ESR antagonist ICI 182 780. Moreover, using letrozole, a drug that blocks estrogen synthesis, we demonstrate that these genes are under the control of E2 within rat ST. Thus, germ cell differentiation may be regulated by E2 which acts through ESRs and GPER, expressed in adult rat ST. |
Cote du document numérique : | 17355 |
Classement cheval : | C01 |
En ligne : | non |